From left: Xinying Zong, PhD. Yongqiang Feng, PhD; and Dr. Xiaolei Hao (all of St. Jude Immunology) are studying ways to control effector and killer T cells to destroy treatment-resistant cancer cells. Credits: St. Jude Children’s Research Hospital
Effector and killer T cells are a type of immune cell. Their job is to attack pathogens and cancer. These cells can also target normal cells that cause autoimmune diseases. However, when used properly, it can destroy cancer cells that resist treatment.
Scientists at St. Jude wanted to understand how these T cells are regulated.They saw EnhancerA sequence of DNA that determines how a gene turns on or off when it binds to a particular protein.
Scientists have discovered that a gene enhancer named Foxp3 acts as a pair to suppress effector T cells and killer T cells. Enhancers that work together are essential.
These enhancers work together like your left and right hands, said Dr. Yong Feng of St. Jude Immunology. They work together in a variety of ways to suppress effector and killer T cells. Immune system Try to attack only the right targets. “
Is Experimental Medical Journal This work has been released.
How transcription factors work together in cancer formation
For more information:Xinying Zong et al., Foxp3 Enhancer Synergistically Maximizes Regulatory T Cell Suppression Capability Experimental Medical Journal (2021). DOI: 10.1084 / jem.20202415
Provided bySt. Jude Children’s Research Hospital
Quote: A team studying how effector and killer T cells can be controlled to destroy treatment-resistant cancer cells (June 4, 2021) Cytotoxic T cells.html
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Team researching how effector and killer T cells can be controlled to destroy cancer cells that resist treatment Source link Team researching how effector and killer T cells can be controlled to destroy cancer cells that resist treatment
