The Old Trafford clash against old rivals Liverpool is the third of three games in five days for United following a fixture pile-up.
United beat Aston Villa 3-1 at Villa Park on Sunday to kickstart the run with a win, but Ole Gunnar Solskjaer – who was furious with the Premier Leagues scheduling – made 10 changees for Tuesdays home game against Leicester City.
Solskjaer named virtually a second-string XI featuring the likes of Amad Diallo, Anthony Elanga and Donny van de Beek, and Leicester left Old Trafford with a 2-1 win.
The upside to that result is that Solskjaer was able to rest near enough his whole starting lineup before the Liverpool game, meaning there will be wholesale changes again.
Dean Henderson will return in goal, as will Aaron Wan-Bissaka and Luke Shaw at wing-back – though Maguire is definitely out with ankle ligament damage.
With Victor Lindelof likely to return at centre-back, Solskjaer must pick either Eric Bailly or Axel Tuanzebe to partner him – and while the latter fared better against Leicester, Bailly should get the nod.
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In midfield, Fred and Scott McTominay will come back in, while Paul Pogba, Bruno Fernandes and Edinson Cavani are likely to start.
The key decision in attack will be whether Solskjaer opts for Mason Greenwood or Marcus Rashford on the right flank. Greenwood is in far better form, and the fact that he came off with time to spare against Leicester suggests that was a substitution to save him for this game.
As for injuries, Maguire joins Dan James, Anthony Martial and Phil Jones on the sidelines.
Man Utd predicted XI: (4-2-3-1) Henderson; Wan-Bissaka, Bailly, Lindelof, Shaw; Fred, McTominay; Greenwood, Bruno Fernandes, Pogba; Cavani
Injury list: Maguire, Martial, Jones, James
Manchester United provisional squad: De Gea, Henderson, Grant, Wan-Bissaka, Williams, Lindelof, Bailly, Tuanzebe, Shaw, Telles, Matic, McTominay, Fred, Pogba, Fernandes, Mata, Diallo, Van De Beek, Elanga, Rashford, Greenwood, Cavani.